Amarax 2 Dosage/Direction for Use

Initial: 1-2 mg once daily, administered with breakfast or the first main meal.
Maintenance dose: 1-4 mg once daily; after a dose of 2 mg once daily, increase in increments of 2 mg at 1 to 2 week intervals based upon the patient's blood glucose response to a maximum of 8 mg once daily. If inadequate response to maximum dose, combination with metformin may be considered.
Combination with insulin therapy: Initial dose is 8 mg once daily with the first main meal or as prescribed by the physician.
Change over from other oral antidiabetics to Glimepiride: There is no exact dosage relationship between glimepiride and other blood-sugar-lowering agents. When substituting glimepiride for others, the initial daily dose is 1 mg, this applies even changeovers from the maximum dose of another oral blood-sugar-lowering agent.
Geriatric use: The initial dosing, dose increment and maintenance dosage should be conservative based upon blood glucose levels prior to and after initiation of treatment to avoid hypoglycemic reactions.
Renal insufficiency: Starting dose of 1 mg of glimepiride may be given to Type 2 diabetic patients with kidney disease, and the dose may be titrated based on fasting blood glucose levels.
Hepatic insufficiency: No studies were performed in patients with hepatic insufficiency.